Romanian Society of Pharmaceutical Sciences
 

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CAPSAICIN MICROEMULSIONS: PREPARATION, CHARACTERIZATION AND IN VITRO RELEASE STUDY

MARIA POPESCU1, LUMINITA CHIUTU2*, CONSTANTIN MIRCIOIU3, ŞTEFAN DIMA4

1.CHU-Guadeloupe, Pointe à Pitre/Abymes, Route de Chauvel 97159, France
2.UMF Craiova, Romania
3.Carol Davila University of Medicine and Pharmacy Faculty of Pharmacy, 6 Traian Vuia, Bucharest, Roumania,
4.Dunărea de Jos University of Galaţi, Department of Chemistry, Physics and Environment, 111 Domnească , 800008, Galaţi, Roumania

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In this study, pseudoternare phase diagrams were made and oil: water: surfactant: cosurfactant (O:W:S:CoS) weight ratios corresponding to microemulsion states were highlighted. Soybean oil was used as the oily phase (O) and a mixture of water and glycerol in a ratio of 4:1 (wt / wt) was used as the aqueous phase (W). As a surfactant (S) was used sorbitan monooleate (Span 80) and cosurfactants (CoS) were ethanol and 1- butanol in the mass ratio S: CoS = 2:1. Viscosimetric and conductometric analyses revealed the transition state of the O/W, W/O microemulsions and bicontinuous structures. In vitro study of capsaicin release and permeability was performed using a Franz cell, with a cellulose membrane. As a liquid receiver was used a liquid mixture 1:1 (v/v) of ethanol and citric acid - disodium phosphate buffer, with pH = 7.4 at a temperature of 37oC. The drug content of capsaicin was analysed by a HPLC technique. It was determined capsaicin optimal concentration of 0.12% (wt/wt). The microemulsions behaviour as a better vehicle than gel behaviour and ethanol action as a better permeation enhancer than 1-butanol were demonstrated. A clinical trial on capsaicin microemulsions use as improving method of blood collecting for obstructive pulmonary disease (OPD) diagnostic was conducted. The results confirm the high potential of microemulsions as topical drug vehicles.