Romanian Society of Pharmaceutical Sciences
 

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BIOAVAILABILITY OF VALPROATE SUPPOSITORIES FORMULATED FOR PAEDIATRIC USE

NICOLETA TODORAN 1, ADRIANA CIURBA 1*, SZENDE VANCEA 2, CAMIL-EUGEN VARI 3, MARIA-TITICA DOGARU 3, ALEXANDRINA TĂUREAN 4, DANIELA-LUCIA MUNTEAN 5, ROBERT-ALEXANDRU VLAD 1, FELICIA GLIGOR 6

1.University of Medicine and Pharmacy of Tîrgu Mureş, Faculty of Pharmacy, Department of Pharmaceutical Technology, 38 Gh. Marinescu Street, 540139, Târgu Mureș, Romania
2.University of Medicine and Pharmacy of Tîrgu Mureş, Faculty of Pharmacy, Department of Physical Chemistry, 38 Gh. Marinescu Street, 540139, Târgu Mureș, Romania
3.University of Medicine and Pharmacy of Tîrgu Mureş, Faculty of Pharmacy, Department of Pharmacology and Clinical Pharmacy, 38 Gh. Marinescu Street, 540139, Târgu Mureș, Romania
4.Pharmacy no.3, Emergency Clinical County Hospital of Târgu Mureș, 50 Gh. Marinescu Street, 540136, Târgu Mureș, Romania
5.University of Medicine and Pharmacy of Tîrgu Mureş, Faculty of Pharmacy, Department of Analytical Chemistry and Analysis of Medicine, 38 Gh. Marinescu Street, 540139, Târgu Mureș, Romania
6.“Lucian Blaga” University, Faculty of Medicine, Department of Biochemistry, 10 Victoriei Blvd., 550024, Sibiu, Romania

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Considering that the rectal route might eliminate the time-dependent changes of valproic acid kinetics and starting from the need to develop suppositories for paediatric use, in our previous studies three types of valproate suppositories were selected for further in vivo investigation. In this paper, the experimental pharmacokinetic study conducted on rabbits is presented, in order to evaluate the relevant in vivo pharmacokinetic parameters. The parameters obtained after a single rectal dose over a period of 8 h, were analysed in each case by the non-compartmental pharmacokinetic model. The similarity of the three release profiles previously found in vitro has not fully confirmed the in vivo parameters, which shows that the in vivo pharmacokinetic test still remains necessary in case of studies on the development of suppositories formulation.