Romanian Society of Pharmaceutical Sciences
 

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ATR-IR AND RAMAN SPECTROSCOPIC STUDY OF INTERACTION BETWEEN MAJOR CALIXARENE DERIVATIVES AND ORAL ANTICOAGULANTS

IOANA TIUCA1*, ALINA SAPONAR2, ANDREEA BODOKI3, ERIC ZIÉMONS4, EDE BODOKI1, PHILIPPE HUBERT4, RADU OPREAN1

1Analytical Chemistry Department, Faculty of Pharmacy, University of Medicine and Pharmacy “Iuliu Hatieganu”, 4 Pasteur L. st, Cluj-Napoca, Romania
2Inorganic Chemistry Department, Institute for Research in Chemistry, 30 Fântânele st, Cluj-Napoca, Romania
3Inorganic Chemistry Department, Faculty of Pharmacy, University of Medicine and Pharmacy “Iuliu Hatieganu”, 12 Creangă I. st, Cluj-Napoca, Romania
4Laboratory of Analytical Chemistry, CIRM, Department of Pharmacy, Faculty of Medicine, University of Liège, 1 Avenue de l’Hôpital, Liège, Belgium

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In this study we analyzed by ATR-IR and Raman spectroscopy the interaction between six major calixarene derivatives and two anticoagulants: warfarin and acenocoumarol. The six calixarene derivatives were: p-tert-butyl-calix[4]arene (C4), p-tertbutyl- calix[6]arene (C6) and p-tert-butyl-calix[8]arene (C8) and their ethyl-esterderivatives: tetraester-p-tert-butyl-calix[4]arene (C4Es4), hexaester-p-tert-butylcalix[ 6]arene (C6Es6), octaester-p-tert-butyl-calix[8]arene (C8Es8). The results showed the most intense interaction in terms of complex formation for the C6-acenocoumarol couple and for the C6-warfarin couple, respectively.