Romanian Society of Pharmaceutical Sciences
 

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ASSESSMENT OF THE GRANULATION PROCESS EFFECT ON MORPHO-ANATOMICAL FEATURES AND BIOLOGICALLY ACTIVE SUBSTANCES COMPOSITION OF SENNA LEAVES

OLGA TRIFONOVA 1,2, OLGA EVDOKIMOVA 3, VERA PROKOFIEVA 4, HELGI SCHIÖTH 5,6, ALEXEY MATYUSHIN 7,8*

1.Department of Pharmacy, Sechenov First Moscow State Medical University, Moscow, Russian Federation
2.JSC “Krasnogorsklersredstva”, Krasnogorsk, Russian Federation
3.Federal State Budgetary Institution Scientific Centre for Expert Evaluation of Medicinal Products of the Ministry of Health of the Russian Federation, Moscow, Russian Federation
4.A.P. Arzamastsev Department of Pharmaceutical and Toxicological Chemistry, Sechenov First Moscow State Medical University, Moscow, Russian Federation
5.Department of Neuroscience, Uppsala University, Uppsala, Sweden
6.Institute for Translational Medicine and Biotechnology, Sechenov First Moscow State Medical University, Moscow, Russian Federation
7.Department of Analytical and Forensic Toxicology, Sechenov First Moscow State Medical University, Moscow, Russian Federation
8.Institute of Linguistics and Intercultural Communication, Sechenov First Moscow State Medical University, Moscow,
Russian Federation

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Cassia senna L. and Cassia angustifolia Vahl. leaves and their preparations are widely acknowledged herbal drugs. Recent development of a novel dosage form - cut-pressed granules - enhances convenience of use in a home setting. However, manufacturing of cut-pressed granules is feasible only if the quality of the material doesn’t decrease during granulation. The aim of the study was to assess the possible changes in identification parameters and in the composition of biologically active substances in Senna leaves after processing. It was shown that TLC chromatographic profiles of the herbal drug remain unchanged. Spectrophotometric assessment confirmed that the anthracene aglycones content of the herbal material was also not affected by granulation. It can be concluded that the quality of cut-pressed granules obtained from Senna leaves is not inferior compared to the raw material.