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ASSESSMENT OF THE ANTIOXIDANT EFFECT OF A MASLINIC ACID DERIVATIVE IN AN EXPERIMENTAL MODEL OF ACUTE INFLAMMATION

IOANA ZINUCA PAVEL1#, ALINA ELENA PÂRVU2#, CRISTINA ADRIANA DEHELEAN1, LAURIAN VLASE2*, RENÉ CSUK3, DANINA MIRELA MUNTEAN1,4

1.“Victor Babeș” University of Medicine and Pharmacy, 2 Eftimie Murgu Square, RO-300041, Timișoara, Romania
2.“Iuliu Haţieganu” University of Medicine and Pharmacy, 8 Victor Babeş Street, Cluj-Napoca, RO-400012, Romania, Cluj-Napoca, Romania
3.Martin-Luther University Halle-Wittenberg, 2 Kurt-Mothes Street, D-06120, Halle (Saale), Germany
4.Center for Translational Research and Systems Medicine, “Victor Babeș” University of Medicine and Pharmacy, 2 Eftimie Murgu Square, RO-300041, Timișoara, Romania

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Maslinic acid (MA) is a pentacyclic triterpenoid recognized for multiple therapeutic effects including antidiabetic, anti-inflammatory, antitumor, antioxidant and antiviral properties. Structural changes of MA were performed in order to obtain new derivatives with enhanced properties. The aim of the study was to evaluate the effect of a benzylamide derivative of maslinic acid (“EM2”) (Benzyl (2α, 3β) 2,3-diacetoxy-olean-12-en-28-amide) on acute inflammation-induced oxidative stress. The effect of EM2 on oxidative stress was assessed in an experimental model of turpentine oil-induced acute inflammation in rats by measuring total nitrites and nitrates (NOx), total oxidative status (TOS), total antioxidant response (TAR), oxidative stress index (OSI), total thiols (SH) and malondialdehyde (MDA). The compound was administered prior to and after the induction of the inflammation. In the experimental model of acute inflammation only prophylactic administration elicited an antioxidant effect through a decrease of MDA, the effect being comparable to that of diclofenac (p < 0.01).