Romanian Society of Pharmaceutical Sciences
 

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ARE SSRI’S EQUALLY SAFE IN PREGNANCY? FLUOXETINE AND CITALOPRAM EXPERIMENTAL STUDY

BIANCA EUGENIA ÖSZ1, CAMIL EUGEN VARI1*, MELINDA KOLCSÀR1, OVIDIU SIMION COTOI2, MARIUS ȘTEFAN MĂRUȘTERI3, MARIA T. DOGARU1

1.Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, University of Medicine and Pharmacy, Târgu Mureș
2 .Department of Cellular and Molecular Biochemistry, Faculty of Medicine, University of Medicine and Pharmacy, Târgu Mureș
3 .Department of Medical Informatics and Biostatistics, Faculty of Medicine, University of Medicine and Pharmacy, Târgu Mureș

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The aim of the present study was to determine how fluoxetine and citalopram are affecting gestation and fetal development in Wistar rats. Forty sexually mature female rats, divided in two experimental groups received 20 mg/kg body weight fluoxetine or 3 mg/kg body weight citalopram during the entire gestation period starting day one. Drugs were administered by oral route. A control group (20 females) received distilled water by oral gavage in the same conditions. Healthy males were caged with nulliparous females for an entire week. All females were killed with halothane through gas scavenging apparatus untilled death on assumed day 21 of gestation for examination of their uterine contents. The number of healthy foetuses, resorbtions and dead foetuses were noted. In both experimental groups resorbtion occurred and dead foetuses were identified. The resorbtions were confirmed by histopathological analyses. The statistical analysis of results showed that only citalopram is affecting gestation in a significant manner (p<0.01). For fluoxetine the number of resorbtions and death foetuses was not significant different compared with control group (p>0.05).