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ANTIOXIDANT ENZYMES – POTENTIAL TARGETS IN INTRACEREBRAL HAEMORRHAGE

TOMA PAPACOCEA1, IOAN BURAGA2, RALUCA PAPACOCEA3*, IOANA ANCA BADARAU3, MAGDA BURAGA3, CATALINA CIORNEI3, GRAŢIELA MIHAI3, IRINA STOIAN4, ADAM DANIL1

1.Emergency Hospital “St. Pantelimon”, Department of Neurosurgery, 340 Pantelimon, 21659 Bucharest, Romania
2 .Clinical Hospital Colentina, Department of Neurology, 19-21 Ștefan cel Mare 020125 Bucharest, Romania
3 .Physiology Department I, “Carol Davila” University of Medicine and Pharmacy, 8 Eroilor Sanitari, 050474, Bucharest Romania
4 .Biochimistry Department, “Carol Davila” University of Medicine and Pharmacy, 8 Eroilor Sanitari, 050474, Bucharest Romania

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Intracerebral haemorrhage (ICH) is accompanied by a cascade of pathological events which involves the generation of oxygen and nitrogen reactive species. These very short lifetime molecules change the level of antioxidant mechanisms, including antioxidant enzymes. The aim of our study was to assess the superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (Gred), glutathione transferase (GTS) activities. The level of oxidative damage was underlined by malondialdehyde (MDA) as index of lipid peroxidation .We also assessed the total nitrite level. The measurements were performed on cerebrospinal fluid (CSF) samples from 21 patients and 15 healthy volunteers. We found significantly increased SOD and GPx and reduced Gred and GST activities in CSF of ICH patients. MDA and total nitrate levels were both increased.