Romanian Society of Pharmaceutical Sciences

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ANTIOXIDANT ACTIVITY EVALUATION FOR SOME NOVEL CHROMENYL-DERIVATIVES

IOANA IONUŢ 1, DIANA OLTEANU 2*, GABRIEL MARC 1, SIMONA CLICHICI 2, DANIELA BENEDEC 3, BRÎNDUŞA TIPERCIUC 1, OVIDIU ONIGA 1

1.Pharmaceutical Chemistry Department, Iuliu Haţieganu University of Medicine and Pharmacy, 41 Victor Babeş Street, 400012, Cluj-Napoca, Romania
2.Physiology Department, Iuliu Haţieganu University of Medicine and Pharmacy, 1 Clinicilor Street, 400006, Cluj-Napoca, Romania
3.Pharmacognosy Department, Haţieganu University of Medicine and Pharmacy, 12 Ion Creangă Street, 400010, Cluj- Napoca, Romania

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A series of twenty previously reported compounds - chromenyl-thiosemicarbazone and chromenyl-dihydro-thiadiazole derivatives - were screened for their in vitro antioxidant activities, using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. All chromenyl-thiosemicarbazones (1a-j) exhibited better DPPH scavenging activity than butylated hydroxytoluene (BHT) and two of them (1a and 1h) were superior to ascorbic acid. Therefore, they were further investigated, on human umbilical vein endothelial cells (HUVEC) cells, for their influence on oxidative stress, through the 2’7’-dichlorodihydrofluorescein-diacetate (DCDHF-DA) assay. All chromenyl-thiosemicarbazones tested significantly decreased reactive oxygen species (ROS0 production (p < 0.001, compared to the group treated only with H2O2).