Romanian Society of Pharmaceutical Sciences
 

« Back to Farmacia Journal 4/2019

ANTIFUNGAL ACTIVITY AND CHEMICAL COMPOSITION OF ENDOPHYTIC FUNGUS PHANEROCHAETE SP. MFLUCC16-0609

SARUNPRON KHRUENGSAI 1, CHUTIMA TANAPICHATSAKUL 1, SUCHAWADEE INSAWANG 1, SINANG HONGSANAN 2,3, PATCHAREE PRIPDEEVECH 1,4*

1.School of Science, Mae Fah Luang University, Chiang Rai 57100, Thailand
2 .Center of Excellence in Fungal Research, Mae Fah Luang University, Chiang Rai 57100, Thailand
3 .Shenzhen Key Laboratory of Microbial Genetic Engineering, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China
4 .Center of Chemical Innovation for Sustainability (CIS), Mae Fah Luang University, Chiang Rai, Thailand

Download Full Article PDF

The fungal endophytes associated with the O. basilicum var. thyrsiflora and its potential for providing antifungal compounds were investigated. Fourteen fungal endophytes were isolated and cultured. Crude extracts of endophytes showed antifungal properties against Trichoderma reesei and Lasiodiplodia theobromae. The crude extract of MFLUCC16-0609 played a role as a great natural fungicide due to his inhibiting property against T. reesei and L. theobromae compared to other extracts. Two major constituents including sclareolide (42.03%) and muzigadial (19.44%) were detected as the key antifungal compounds. DNA-phylogeny-based and morphology-based genus analysis of strain MFLUCC16-0609 can be reconciled in the Phanerochaete genus. Our results suggest that Phanerochaete sp. MFLUCC16-0609 may be a source of bioactive compounds inhibiting or controlling plant disease pathogens.