Romanian Society of Pharmaceutical Sciences

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ANTIBIOTIC PROPHYLAXIS IN TRANSURETHRAL RESECTIONS: WHAT ARE THE CRITERIA THAT SHOULD BE FOLLOWED?

CĂTĂLIN PRICOP 1,2#, LIGIA FLORENTINA FURTUNESCU 3#, DANIEL RĂDĂVOI 3,4*, VIOREL JINGA 3,4, ALIN CUMPĂNAȘ 5, DANA-TEODORA ANTON-PĂDURARU 6, ADELINA MIRON 2, CRISTIAN TOMA 3, DRAGOȘ PUIA 1,2

1.“Grigore T. Popa” University of Medicine and Pharmacy, Faculty of Medicine, Discipline of Urology, 16 Universităţii Street, 700115, Iaşi, Romania
2.“Dr. C. I. Parhon” Clinical Hospital, Clinic of Urology, 50 Carol I Boulevard, 700503, Iaşi, Romania
3.“Carol Davila” University of Medicine and Pharmacy, Faculty of Medicine, 37 Dionisie Lupu Street, Bucharest, Romania
4.“Prof. Dr. Theodor Burghele” Clinical Hospital, Department of Urology, 20 Panduri Road, Bucharest, Romania
5.University of Medicine and Pharmacy, Faculty of Medicine, Discipline of Urology, Timișoara, Romania
6.“Grigore T. Popa” University of Medicine and Pharmacy, Faculty of Medicine, Department of Mother and Child Medicine, 16 Universităţii Street, Iaşi, Romania

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Antibiotic prophylaxis for urinary tract infections (UTIs) after endourology procedures is a controversial subject. Our objectives are the evaluation of postoperative incidence of bacteriuria and infectious complications after endoscopic surgery, to create a profile for who needs prolonged antibiotic therapy, and to analyse the risk factors that lead to the appearance of postoperative UTIs. We carried out a non-randomized, prospective study. Patients who underwent transurethral resection of bladder tumour (TUR-BT) or transurethral resection of prostate (TUR-P) and had a negative preoperative urine culture were included. Out of 705 subjects TUR-P 13.4%, respectively TUR-BT 7.2% had positive cultures. The encountered bacteria were E. coli, Klebsiella, Enterococcus, and others with MAR index ranging from 0.18 to 0.75 (Pseudomonas). The study suggests that prolonging antibiotics at home is not useful in patients who have undergone TUR-P, but it might decrease the risk of TUR-BT patients. Keeping the urinary catheter for a prolonged time increases the risk of UTIs.