Romanian Society of Pharmaceutical Sciences
 

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ANTIBIOTIC POTENTIATOR EFFECT OF THE NATURAL AND SYNTHETIC ZEOLITES WITH WELL DEFINED NANOPORES WITH POSSIBLE ENT CLINICAL APPLICATIONS

ION ANGHEL1*, ALEXANDRU MIHAI GRUMEZESCU2, ALINA GEORGIANA ANGHEL3, IULIAN CHIREAC4, LUMINITA MARUTESCU4, DAN EDUARD MIHAIESCU2, MARIANA CARMEN CHIFIRIUC4

1University of Medicine Carol Davila Bucharest, Romania
2Politehnica University of Bucharest, Faculty of Applied Chemistry and Materials Science, Bucharest, Romania
3ENT (Otorhinolaryngology) Clinic, Coltea Hospital, Bucharest, Romania
4University of Bucharest, Faculty of Biology, Microbiology Immunology Department, Bucharest, Romania

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An adapted difussimetric method was used in order to assess the potentiator effect of some natural (NZ) and synthetic zeolites (SZ)with well defined nanopores on the antibiotic (ATB) susceptibility of Enterococcus fecalis, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus subtilis and Escherichia coli strains to some of the currently used antibiotics, i.e. neomycin, polymixin, norfloxacin and cefotaxime. Our results show that the natural and synthetic zeolites with well defined nanopores release antibiotics with different chemical structures in an active form and improve their antimicrobial effect against Gram-positive and Gram-negative bacterial strains, constituting promissing delivery systems for various classes of commonly used antibiotics.