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ANTIBACTERIAL AND ANTIFUNGAL ACTIVITY OF SOME 2- AND 1,2-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES

FLORIN AONOFRIESEI 1#, IRINEL-GRAȚIELA MĂNESCU 2#, GABRIELA STANCIU 2*, SIMONA LUPȘOR 2#, MANUELA GHICA 3, MAGDALENA MITITELU 3

1“Ovidius” University of Constanța, Department of Natural Sciences, Faculty of Natural Sciences and Agricultural Sciences, 1 University Street, 900470, Constanța, Romania
2“Ovidius” University of Constanța, Department of Chemistry and Chemical Engineering, Faculty of Applied Sciences and
Engineering, 124 Mamaia Boulevard, 900527, Constanța, Romania
3“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, 6 Traian Vuia Street, 020956, Bucharest, Romania

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Benzimidazoles are a large class of compounds with many clinical and pharmacological applications. At present, there is an intense and renewed effort to synthetize new derivatives starting from the well-known benzimidazole moiety and to explore their properties. Due to the increasing antibiotic resistance of pathogens, a major objective is to find new efficient anti-bacterial agents. In this context, the study was carried out in order to estimate the antimicrobial potential of four 2- and 1,2- substituted benzimidazole derivatives already known to have photoprotective properties. Their antimicrobial capacity was assessed by diffusimetric tests by using 13 bacterial and 7 Candida strains and further completed by Minimum Inhibitory Concentration (MIC), and time-kill assay. The mean values of MIC varied between a minimum of 87.5 µg/mL and a maximum of 200 µg/mL in the Staphylococcus group, while for Candida values between 104.6 µg and 151.78 µg/mL were recorded. The results demonstrate a significant inhibitory activity against Gram-positive bacteria and Candida strains. Experiments of time-kill carried out on Candida showed a concentration-dependent activity pattern.