Romanian Society of Pharmaceutical Sciences
 

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ANTIBACTERIAL ACTIVITY OF ETHANOLIC EXTRACTS FROM FAGUS SYLVATICA L. AND JUGLANS REGIA L. LEAVES

ALINA IOANA NICU 1,2*, LUCIA PÎRVU 2, GHEORGHE STOIAN 3, ADRIAN VAMANU 1

1.Faculty of Biotechnologies, University of Agronomic Science and Veterinary Medicine, 59 Marasti Boulevard, Bucharest, Romania
2.Pharmacology Department, National Institute for Chemical Pharmaceutical Research and Development – ICCF, 112 Vitan Avenue, Bucharest, Romania
3.Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 91-95 Splaiul Independenței, Bucharest, Romania

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The use of medicinal plants is well known and modern science investigates the scientific bases for the effects of numerous plant extracts against a great variety of diseases. Therefore, the aim of this study was to explore the antibacterial activity of the leaves from two Romanian indigenous species: European beech (Fagus sylvatica L.) and walnut (Juglans regia L.). The leaves were dried, then grinded and polyphenols were extracted using ethanol 70%. Afterwards, polyphenols and flavonoids were assayed and identified accurately by HPTLC. Antimicrobial activity of the extracts was tested against several pathogenic bacteria using the agar diffusion method and minimum inhibitory concentration determination. Our results showed a better activity against Gram positive bacteria, and the most susceptible bacterial strain was Staphylococcus epidermidis.