Romanian Society of Pharmaceutical Sciences
 

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ANTI-TUMOR EFFECT OF EUONYMUS EUROPAEUS ON EHRLICH TUMOR CELLS IN VIVO

BOGDAN SEVASTRE1*, ORSOLYA SÁRPATAKI1, NELI K. OLAH2, ROXANA L. STAN3, MARIAN TAULESCU1, IOAN MARCUS1, CORNEL CĂTOI1

1.University of Agricultural Science and Veterinary Medicine, Faculty of Veterinary Medicine, 3/5 Manastur Street, 400372, Cluj-Napoca, Romania,
2.PlantExtrakt Ltd, 407059 Rădaia, Cluj-Napoca, Romania and
Department of Pharmaceutical Industry, Faculty of Pharmacy, "Vasile Goldis" West University of Arad, 1 Feleacului Street, 300041, Romania
3.University of Medicine and Pharmacy “Iuliu Hațieganu”, Faculty of Pharmacy, Department of Pharmaceutical Biochemistry and Clinical Laboratory, 4/6 Pasteur Street, 400349, Cluj-Napoca, Romania

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Euonymus europaeus L., (EE) is the sole representative of Celastraceae family in Europe. The aim of the present study was to investigate EE anticancer effect on an in vivo model. The ethanolic extract was administered in different doses both orally and intraperitoneally in Swiss female mice intraperitoneally implanted with Ehrlich ascitic tumour cells. The EE extract showed a significant antiproliferative effect in a dose dependent manner, the highest dose of 50 mg/kg b.w., reduced the body weight gain (by up to 5%), accumulation of ascitic fluid (by up to 65%), and the tumour cell concentration (by up to 43%) (p<0.05). The inhibitory effect was positively correlated with the concentration of the inflammatory cells into the peritoneal exudate.