Romanian Society of Pharmaceutical Sciences
 

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ANTI α-GLUCOSIDASE, ANTITUMOUR, ANTIOXIDATIVE, ANTIMICROBIAL ACTIVITY, NUTRITIVE AND HEALTH PROTECTIVE POTENTIAL OF SOME SEAWEEDS FROM THE ADRIATIC COAST OF MONTENEGRO

SANJA MILOVIĆ 1, TATJANA KUNDAKOVIĆ 1, VESNA MAČIĆ 2, JELENA ANTIĆ STANKOVIĆ 1, NAĐA GROZDANIĆ 3, IVANA ĐURIČIĆ 1, IVAN STANKOVIĆ 1, TATJANA STANOJKOVIĆ 3*

1.Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, Serbia
2.Institute of Marine Biology, P.O. Box 69, 85330 Kotor, Montenegro
3.Institute of Oncology and Radiology of Serbia, Pasterova 14, 11000 Belgrade, Serbia

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The aim of the present study was to reveal the potential biological activities of the dichlorometane:methanol (1:1) dry extract (DME) and the nutritional value of selected seaweeds: Cymodocea nodosa, Halimeda tuna, Cystoseira barbata and Codium bursa, collected from the Adriatic coast, Montenegro. We assessed the chemical composition and several biological activities such as: anti- α-glucosidase, antitumour, antimicrobial and antioxidative activity. H. tuna had the best cytotoxic activity against human colon carcinoma cell line, LS174 (IC50 = 17.92 ± 1.54 μg/mL). C. nodosa demonstrated strong cytotoxicity against human adenocarcinoma cell line, HeLa (IC50 = 13.28 ± 0.39 μg/mL) and human chronic myelogenous leukaemia cell line, K562 (IC50 = 19.64 ± 1.55 μg/mL). C. barbata had the best anti α-glucosidase (IC50 = 9.98 ± 3.34 µg/mL) and antimicrobial activity (minimal inhibitory concentration of 100 μg/mL) for Staphylococcus aureus and Bacillus subtilis. C. bursa showed the highest nutritional value (490.4 kcal).