Romanian Society of Pharmaceutical Sciences

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ANALYSIS OF ADVERSE REACTIONS RELATED TO PROPHYLACTIC ANTIBIOTHERAPY IN PATIENTS WITH CLASS I ORTHOPAEDIC INCISION

LEQUAN LIU *, JINPING PAN, HUIKANG GUO, SEN LI, JISHENG LI

Department of Arthroplasty, Jincheng General Hospital, Jincheng, 048006, Shanxi, China

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This study was developed to analyse the effect of prophylactic use of antibiotics on postoperative infection and adverse reactions in patients with class I orthopaedic incisions. A total of 120 orthopaedic incision patients undergoing elective surgery were divided into a control group (44 cases, routine antibacterial treatment) and an intervention group (76 cases, preoperative prophylactic antibiotics). The time of using antibiotics, types of drugs, combination drugs, the rate of additional antimicrobial requests, length of hospital stay, cost of antibiotics and adverse reaction rate were compared between the two groups. Compared with the control group, the use rate of antibiotics in the intervention group increased within 0.5 h before the operation, 0.5 - 2 h and 2 h after the operation and within 24 h after the operation, the use rate of class I cephalosporin antibiotics increased, the use rate of antibiotics alone increased, the rate of additional antimicrobial request for patients with an operation time exceeding 3 h decreased and the average cost of antibiotics decreased. Compared with the control group, the intervention group had a drastically lower adverse reaction rate and postoperative infection rate. In conclusion, the preoperative administration of reasonable and standardized prophylactic antibiotics can effectively reduce the incidence of postoperative infection and adverse reactions in patients with class I orthopaedic incisions and reduce the cost of treatment.