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A NEW FORMULATION OF CINNAMON OIL AND CHITOSAN DEPOLYMERIZED AGAINST OPPORTUNISTIC MICROORGANISMS DURING WOUND HEALING

MARÍA LUISA DEL PRADO-AUDELO 1,2, ADRIANA ESTELA HERNÁNDEZ-TENORIO 1,
MAYKEL GONZÁLEZ-TORRES 3, JONATHAN J. MAGAÑA 4, ROBERTO SÁNCHEZSÁNCHEZ 5, MARÍA DEL PILAR GRANADA-MACÍAS 6, SILVESTRE ORTEGA-PEÑA 7,
HERNÁN CORTES 4, GERARDO LEYVA-GÓMEZ 1*

1Department of Pharmacy, Faculty of Chemistry, National Autonomous University of Mexico, Ciudad Universitaria, Circuito Exterior S/N, Del. Coyoacán, Mexico City, Mexico
2 Graduate Laboratory in Pharmaceutical Technology, FES-Cuautitlán, National Autonomous University of Mexico, Cuautitlán Izcalli, Mexico
3 CONACyT-Biotechnology Laboratory, National Institute of Rehabilitation Luis Guillermo Ibarra Ibarra, Mexico City, Mexico
4 Genomic Medicine Laboratory, Department of Genetics, National Center for Research and Attention to Burns (CENIAQ),
National Institute of Rehabilitation-Luis Guillermo Ibarra Ibarra (INR-LGII), Mexico City, Mexico
5 Tissue Engineering Unit Cell Therapy and Regenerative Medicine, National Institute of Rehabilitation Luis Guillermo Ibarra Ibarra (INR-LGII), Mexico City, Mexico
6 Department of Biology, Faculty of Chemistry, National Autonomous University of Mexico, Ciudad Universitaria, Circuito
Exterior S/N, Del. Coyoacán, Mexico City, Mexico
7 Laboratory of Infectology, National Institute of Rehabilitation Luis Guillermo Ibarra Ibarra, Mexico City, Mexico

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Infectious processes may delay wound healing. In this regard, there are diverse treatments available to prevent infections and promote wound healing. However, many of these present drawbacks, such as bacterial resistance, decrease their efficacy. In this respect, chitosan, a natural polymer with antibacterial and antifungal properties, may be useful in the process of skin repair. In this work, a cinnamon oil-based formulation with chitosan modified by gamma irradiation was developed. Moreover, disodium EDTA was added to create a combined antimicrobial effect against infections. The novel formulation showed percentages of inhibition of 43.64% for E. coli, 42.86% for P. aeruginosa, 80.27% for C. albicans, and 42.31% for S. aureus, as well as antibiofilm activity against P. aeruginosa. Our results suggest that the obtained formulation could be a new alternative treatment for chronic wounds.