Romanian Society of Pharmaceutical Sciences
 

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A COMPARATIVE PHARMACOGNOSTIC STUDY AND ASSESMENT OF ANTIOXIDANT CAPACITY OF THREE SPECIES FROM PLANTAGO GENUS

PAOLINA LUKOVA 1*, DIANA KARCHEVA-BAHCHEVANSKA 1, IVANKA DIMITROVA-DYULGEROVA 1,2, PLAMEN KATSAROV 3, RUMEN MLADENOV 1,2, ILIA ILIEV 4, MARIANA NIKOLOVA 4

1.Department of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University – Plovdiv, Plovdiv, Bulgaria
2.Department of Botany and Teaching Methods in Biology, Faculty of Biology, University of Plovdiv “Paisii Hilendarski”, Plovdiv, Bulgaria
3.Department of Pharmaceutical Sciences, Faculty of Pharmacy, Medical University – Plovdiv, Plovdiv, Bulgaria
4.Department of Biochemistry and Microbiology, Faculty of Biology, University of Plovdiv “Paisii Hilendarski”, Plovdiv, Bulgaria

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This paper presents a comparative pharmacognostic study of three species from Plantago genus (Plantago media L., Plantago major L., Plantago lanceolata L.) and assessment of their antioxidant capacity. First time reported microscopic data of P. media leaves revealed the presence of multicellular covering trichomes, stalked glandular trichomes, anomocytic and diacityc stomatal type. The phytochemical analysis showed that P. media leaves had the highest content of polysaccharides (24.43%) and total polyphenols (28.91 mg GAE/g dw), whereas P. lanceolata leaves were the richest source of chlorophyll (40.38 mg/L). Antioxidant activity of ethanol extracts from Plantago leaves were characterized by DPPH (2,2-diphenyl-2-picryl-hydrazyl-hydrate) scavenging test, CUPRAC (cupric reducing antioxidant capacity) and FRAP (ferric reducing anti-oxidant power) assays. All extracts showed significant antioxidant efficacy and among them P. media extracts exhibited the strongest antioxidant activity in the three methods.