RENOPROTECTIVE AND HEPATOPROTECTIVE EFFECTS OF HIPPOCRATEA EXCELSA ON METABOLIC SYNDROME IN FRUCTOSE-FED RATS
ELIZABETH ALEJANDRINA GUZMÁN HERNÁNDEZ 1,2*, SILVANA ANDREA DÍAZ PORTILLO 1, ÓSCAR CRISTÓBAL VILLAFUERTE ANAYA 1, MARÍA DEL ROSARIO GONZÁLEZ VALLE 3, JOSÉ DEL CARMEN BENÍTEZ FLORES 3, RUBÉN SAN MIGUEL CHÁVEZ 4, GLADYS CHIRINO GALINDO 5, LEONARDO DEL VALLE MONDRAGÓN 6, DAVID SEGURA COBOS 2, GIL ALFONSO MAGOS GUERRERO 7, PEDRO LÓPEZ SÁNCHEZ 1
1Postgraduate Studies and Research Section, Higher School of Medicine, National Polytechnic Institute, Mexico City, 11340, Mexico 2Medical Surgeon Career, Faculty of Superior Studies Iztacala, National Autonomous University of Mexico, Tlalnepantla, State of Mexico, 54090, Mexico 3Histology Laboratory, Morphology and Function Unit, Faculty of Superior Studies Iztacala, National Autonomous University of Mexico, Tlalnepantla, State of Mexico, 54090, Mexico 4Phytochemistry Area, Postgraduate Degree in Botany, Campus Montecillo, Postgraduate College, Km. 36.5 México-Texcoco Road, Montecillo, Texcoco, State of Mexico, C.P. 56230, Mexico 5Biology Career, Faculty of Superior Studies Iztacala, National Autonomous University of Mexico, Tlalnepantla, State of Mexico, 54090, Mexico 6Department of Pharmacology, National Institute of Cardiology Ignacio Chávez, Mexico City, C.P. 04510, Mexico 7Department of Pharmacology, Faculty of Medicine, National Autonomous University of Mexico, Coyoacán, Mexico City, C.P. 04510, Mexico *corresponding author: shponia2000@yahoo.com.mx
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Abstract:
The metabolic syndrome is associated with the development of chronic kidney disease and liver damage. The aim of this research was to determine the effect of the ethanol bark extract of Hippocratea excelsa (HE) on high fructose consumption-induced adverse effects in the kidney and liver of rats. Rats with 20% fructose feeding for 12 weeks showed arterial hypertension, obesity, dyslipidaemia and developed oxidative stress, proteinuria, the activities of antioxidant enzymes in the renal cortex and liver were decreased, TGF-1 increased, and kidney and liver damage were observed. After the treatment for 6 weeks with HE (30 and 100 mg/kg bw) renoprotective and hepatoprotective effects in high fructose induced metabolic syndrome in rats, were demonstrated.






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