PHYSICO-CHEMICAL CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY OF A CONTROLLED COLLAGENHYDROXYAPATITE-CIPROFLOXACIN RELEASE SYSTEM
MARIA-VIORICA CIOCÎLTEU 1, OANA-LILIANA FILIP (IONESCU) 1*, COSTEL VALENTIN MANDA 1, OANA-ELENA NICOLAESCU 1, IONELA ANDREEA NEACȘU 2, ANTON FICAI 2, IULIANA-MIHAELA BUZATU 3, CLAUDIU NICOLICESCU 4, OCTAVIAN CROITORU 1, JOHNY NEAMŢU 1
1Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2-4 Petru Rareș Street, 200349, Craiova, Romania 2Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 1-7 Polizu Street, 011061, Bucharest, Romania 3Primary Physician, Fundeni Clinical Institute, Laboratory for Medical Analysis in the Microbiology Department, 258 Fundeni Street, 022328, Bucharest, Romania 4Department of IMST, Faculty of Mechanics, University of Craiova, 1 Călugăreni Street, 220037, Drobeta Turnu Severin, Romania *corresponding author: oanaionescu611@yahoo.com
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Abstract:
The aim of our study was to synthesize a biocomposite material using a natural polymer (collagen), hydroxyapatite and ciprofloxacin. We used Fourier-transform infrared spectroscopy (FT-IR), dynamic light scattering (DLS), high performance liquid chromatography (HPLC-DAD) and scanning electron microscopy (SEM) for the physico-chemical characterization and we determined its antibacterial activity against Staphylococcus aureus Rosenbach (S. aureus), Pseudomonas aeruginosa (Schroter) Migula (P. aeruginosa), Klebsiella pneumonia (Schroter) Trevisan (K. pneumoniae) and Escherichia coli (Migula) Castellani and Chalmers (E. coli). The release profile of the ciprofloxacin chemisorbed in the material was also studied, and we found that the release was sustained for 30 days.

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