2-AMINO-1,3,4-THIADIAZOLE DERIVATIVES AS POTENTIAL ANTI-HELICOBACTER PYLORI AGENTS – AT A GLANCE
GEORGETA ŞERBAN 1*, IRINA KACSO 2
1University of Oradea, Faculty of Medicine and Pharmacy, Pharmaceutical Chemistry Department, 29 Nicolae Jiga Street, 410028, Oradea, Romania 2National Institute for Research and Development of Isotopic and Molecular Technologies, Department of Biomolecular and Molecular Physics, 67-103 Donath Street, 400293, Cluj-Napoca, Romania
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Abstract:
Helicobacter pylori is a major human pathogen that causes gastric and extra-gastric complications and infects around 50% of the global population. Gastric cancer is a serious consequence of H. pylori infection. About 89% of all gastric cancers can be attributed to this pathogen. Treatment is indicated for all infected patients, as a strategy to knock down the risk of gastric malignancy. Due to the high level of antimicrobial resistance, new medicines are needed to treat H. pylori infection. This paper presents 2-amino-1,3,4-thiadiazole derivatives which exhibited anti-H. pylori effect. Some of the reported compounds showed higher activity compared to standard drugs, making the 2-amino-1,3,4-thiadiazole core a possible pattern for future anti-H. pylori agents.

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