STABILITY AND RHEOLOGICAL PROPERTIES OF NOURIVAN™/ANTIOX BASE WITH SELECTED SOLVENTS
BEATA SZULC-MUSIOŁ 1*, LUCYNA BUŁAŚ 1, BARBARA DOLIŃSKA 1, JUSTYNA KOŁODZIEJSKA 2
1Department of Pharmaceutical Technology, School of Pharmacy and Division of Laboratory Medicine, Medical University of Silesia, Katowice, Poland
2Department of Applied Pharmacy, Medical University of Łódź, Poland
*corresponding author: bszulc@sum.edu.pl

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Abstract:
The basic parameters of the Nourivan™/Antiox base were analysed. The base was mixed in a 1:1 ratio with water, 96% ethanol, castor oil, glycerol and in a ratio of 1:0.5 with castor oil and Peru balsam. The prepared formulations were subjected to rheological tests immediately after preparation and after 4 months since their preparation. Rheological tests were carried out using a Brookfield digital rheometer. It was found that the support retains its homogeneous form when mixed with water, castor oil (1:0.5), ethanol, Peru balsam, glycerol, both on the day of preparation and after the stability test. In rheological tests of the substrate, the lowest rheological stability was demonstrated for the combination with the Peru balsam. The value of the yield stress of the base with the content of Peru balsam was three times lower after 4 months of storage than marked ex tempore. The studies carried out will make it possible to assess the risk of using Nourivan™/Antiox® base for formulation with active substances suspended or dissolved in the described solvents.

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