THE ANTIOXIDANT POTENTIAL EVALUATION OF DICLOFENAC DERIVATIVES WITH HYDRAZONES STRUCTURE
ALIN FOCȘA 1, ANDREEA IACOB 1, IOANA VASINCU 1, SANDRA CONSTANTIN 1, LOREDANA ANDRIESCU 1, ALEXANDRU SAVA 1, FRÉDÉRIC BURON 2, SYLVAIN ROUTIER 2, LENUŢA PROFIRE 1*
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universității Street, 700115, Iaşi, Romania
2Institute of Organic and Analytical Chemistry, University of Orléans - Pôle de Chimie, Chartres Street, 45067, Orléans, France
*corresponding author: lenuta.profire@umfiasi.ro


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Abstract:
A series of diclofenac hydrazones was synthesized and the structure of the compounds was proved using different spectral methods such as infrared (IR), nuclear magnetic resonance (1H-NMR) and high resolution mass spectroscopy (HR-MS). The biological evaluation, focused on in vitro antioxidant effects using DPPH (2,2-diphenyl-1-picrylhydrazyl) and ABTS (2,2’-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid)) free radicals scavenging assays was also performed. An improved antioxidant effect of the synthesized compounds compared to diclofenac was observed.






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