SPONGIOUS FILLERS BASED ON COLLAGEN - HYDROXYAPATITE - EUGENOL ACETATE WITH THERAPEUTIC POTENTIAL IN BONE CANCER
ALINA F. VLADU 1, STEFANIA MARIN 2,3, IONELA A. NEACȘU 1, ROXANA D. TRUŞCĂ 1, MĂDĂLINA G. ALBU KAYA 2, DURMUS A. KAYA 4, ANA-MARIA POPA 5, CĂTĂLINA POIANĂ 6, IOAN CRISTESCU 6*, CRISTINA ORLOV 5, DENISA FICAI 1, ANTON FICAI 1,7, DENISA I. UDEANU 6, BRUNO ȘTEFAN VELESCU 6, TAXIARCHIS KONSTANTINOS NIKOLOUZAKIS 8, LEONID GUREVICH 9, ANDREY N. KUSKOV 10,11, CORNELIA NIȚIPIR 5,6
1University Politehnica of Bucharest, Faculty of Applied Chemistry and Materials Science, 060042, Bucharest, Romania
2Collagen Department, Division Leather and Footwear Research Institute, National Research and Development Institute for Textile and Leather, 031215 Bucharest, Romania
3Center of Surface Science and Nanotechnology, University Politehnica of Bucharest, 060042 Bucharest, Romania
4Department of Field Crops, Agriculture Faculty, Hatay Mustafa Kemal University, Antakya, Turkey
5Clinic of Medical Oncology, Elias University Emergency Hospital, Bucharest, Romania
6“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
7Academy of Romanian Scientists, Bucharest, Romania
8Laboratory of Toxicology, University of Crete, Voutes, Heraklion, Crete, Greece
9Department of Materials & Production, Aalborg University, Skjernvej 4A, Aalborg, Denmark
10Department of Technology of Chemical Pharmaceutical and Cosmetic Products, D. Mendeleev University of Chemical Technology of Russia, Moscow, Russian Federation
11Department “Chembiotech”, Moscow Polytechnic University, Moscow, Russian Federation
*corresponding author: ioancristescu@yahoo.com
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Abstract:
The aim of this study was to develop and characterize composite materials based on collagen, hydroxyapatite and eugenol acetate as new filler biomaterial for the reconstruction of the tissue damage arising after the resection in case of bone cancer. Composite gels consisting of collagen and hydroxyapatite in different proportions (Coll:HAp - 100:0; 70:30; 40:60 - w/w) and 0.5% eugenol acetate were lyophilized and spongious fillers were obtained. The fillers were characterized by water absorption, enzymatic degradation and examined by optical and scanning electron microscopy, EDS, FT-IR spectroscopy while eugenol acetate release from the compositions was also studied. The results showed that the filler with optimal composition (Coll-HAp - 40:60 w/w) completely degrade over about 48 hours, the release capacity being longer during the 144 hours. The complex results obtained from physical-chemical, morphological and eugenol acetate release profile evaluation for the designed composite materials based on collagen and hydroxyapatite testify these formulations as drug delivery systems with potential applications as fillers in orthopaedic field in bone cancer.
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