A NOVEL METHOD FOR THE EXTRACTION OF THE MAIN COMPOUNDS FROM THE ESSENTIAL OIL OF CLOVE BUDS
NIKOLAY N. BOYKO ¹a,b*, ELENA T. ZHILYAKOVA ¹b, DMITRIY I PISAREV ², OLEG O. NOVIKOV ², RITA V. SAHAIDAK-NIKITIUK ³a, VICTORIA YU. KUZNIETSOVA ³b, OLEG S. SHPYCHAK 3c, ALEKSANDR V. TKACHEV 4a, ANATOLIY M. KOVALENKO 4b, NATALIA A. SUSHCHUK 5
¹Laboratory of Technology of Drugsa, Department of Pharmaceutical Technologyb, Department of General Chemistryc, Belgorod National Research University, 85 Pobedy Street, Belgorod, Russia
²Shared Knowledge Center (Research and Educational Center) “Drugs’ quality control center” Рeoples’ Friendship University of Russia, 8/2 Miklukho-Maklay Street, Moscow, Russia
³Department of Processes and Apparatuses of Chemical and Pharmaceutical Industriesa, Department of Chemistry of Natural Compoundsb, Department of Industrial Pharmacy and Economy Institute for Advanced Training of Pharmacy Specialistsc of National University of Pharmacy, 53 Pushkinska Street, Kharkiv, Ukraine
4Department of General and Private Zootechnicsa, Department of Infectious and Invasive Pathologyb, Belgorod State Agricultural University named after V. Gorin, Federal State Budgetary Educational Institution of Higher Education, 3 Vavilova Street, Belgorod, Russia
5Department of Technology of Drugs, Odessa National Medical University, 2 Valikhovsky Lane, Odessa, Ukraine
*corresponding author: boykoniknik@gmail.com


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Abstract:
The purpose of this work was to test a hypothesis about the possibility of extraction of the main clove buds essential oil substances from with two different types of perfluoro organic solvents, Novec 1230 and Novec 7100. Using simple maceration method, it was found out that the maximum yield of eugenol was observed into n-hexane: 81 ± 4%. The yield of eugenol into perfluoro organic solvent Novec 7100 was 73 ± 4% and into the perfluoro organic solvent Novec 1230 was 6.9 ± 0.4%. Using the extraction circulation method, it was found that the yield of eugenol into perfluoro organic solvent Novec 7100 in 2 h of circulation was 85 ± 4%. Under the same conditions, the yield of eugenol into the perfluoro organic solvent Novec 1230 was 54 ± 3% during 4 h of its circulation.






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