THE ETHANOLIC STEM EXTRACT OF CARYOPTERIS X CLANDONENSIS POSSESES ANTIPROLIFERATIVE POTENTIAL BY BLOCKING BREAST CANCER CELLS IN MITOSIS

OANA SICORA *, MARA ANA NAGHI, IOSIF SOOS, COSMIN SICORA

Biological Research Center Jibou, 16 Wesselenyi Street, 455200, Jibou, Sălaj County, Romania

*corresponding author: oanasavuro@yahoo.com

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Abstract:
In the present study it was evaluated the antiproliferative activity of Caryopteris x clandonensis ethanolic stem extract on MCF-7 breast cancer cells. To characterize the effects of the extract on the treated cells the MTT cytotoxicity assay, DAPI staining and agarose gel electrophoresis, were performed. The cytotoxicity of the ethanolic extract of Caryopteris x clandonensis is concentration-dependent and the breast cancer cells treated with this extract are highly affected showing a modified nucleus, an increased mitotic index and subsequently, cell destruction. These findings demonstrate the ethanolic extract has antiproliferative effect on breast cancer cells.

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