VITAMIN D EFFECTS ON LIPID PROFILE AND URIC ACID LEVELS IN THE EXPERIMENTAL MODEL OF METABOLIC DISORDERS IN FRUCTOSE FED WISTAR RATS

LILIA PASHOVA-STOYANOVA 1*, ANNA TOLEKOVA 1, MARIA GANEVA 1, ZHIVKA TSOKEVA 1, PETYA HADZHIBOZHEVA 1, TSVETELIN GEORGIEV 1, KRASIMIRA NANCHEVA 2

1Department of Physiology, Pathophysiology and Pharmacology, Faculty of Medicine, Trakia University, Stara Zagora, Bulgaria
2Department of Internal Medicine and Clinical Laboratory, University Hospital “Prof. Dr. Stoyan Kirkovich”, Stara Zagora 6000, Bulgaria

*corresponding author: lils@gbg.bg

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Abstract:
A growing number of studies suggest that hyperuricemia and low vitamin D levels could contribute to the pathogenesis of metabolic disorders and the development of metabolic syndrome and vice versa - the development of metabolic disorders itself could lead to low vitamin D levels and high uric acid levels. The present study aims to investigate the role of vitamin D effects on uric acid levels and lipid profile in the experimental model of metabolic disorders in fructose fed male Wistar rats. In our study we confirmed the protective role of vitamin D and its effects in lowering the elevated uric acid levels. Vitamin D decreases glucose and uric acid concentrations and improves the cardiogenic lipid profile (cholesterol/HDL and LDL/HDL).

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