THE USE OF NUTRITIONAL SUPPLEMENT IN ROMANIAN PATIENTS – ATTITUDES AND BELIEFS

DAN NICOLAE PĂDURARU 1,2#, FLORENTINA COMAN 1, EMMA ADRIANA OZON 1#, FLORENTINA GHERGHICEANU 1, OCTAVIAN ANDRONIC 1,2*, DANIEL ION 1,2, MARIUS STĂNESCU 3, ALEXANDRA BOLOCAN 1,2

1The University of Medicine and Pharmacy “Carol Davila” Bucharest
2Emergency University Hospital of Bucharest
³Central University Emergency Military Hospital “Carol Davila”, 134 Calea Plevnei, Bucharest, Romania

*corresponding author: andronicoctavian@gmail.com
#Authors with equal contribution.


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Abstract:
Aerial part extracts of Kitaibelia balansae Boiss. were examined for their phenolic contents, as well as anti-inflammatory activities. The chemical compositions of the extracts were analysed by spectrophotometric and chromatographic (HPLC/ MS/MS and HPLC-PDA) approaches. To measure anti-inflammatory activity, the effects of the extracts on nitric oxide (NO) and Tumour Necrosis Factor-α (TNF-α) levels were measured in lipopolysaccharide (LPS) treated murine macrophage cell line (RAW 264.7). The ethyl acetate fraction was found to be abundant in phenolic compounds (259.78 ± 15.07 mgGAE/ gextract). Rutin was identified as the major compound in all the extracts. The ethyl acetate fraction potentially inhibited NO and TNF-α production (37.26 µM and 1781.524 pg/mL, respectively, 6 h) in LPS induced cells.






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