ANTIOXIDANT AND ANTIMICROBIAL POTENTIAL OF NEW
AZETIDIN-2-ONE OF FERULIC ACID
MARIA DRĂGAN 1#, OANA DRAGOSTIN 2#, ANDREEA IACOB 1#, LENUŢA PROFIRE 1#, CĂTĂLINA DANIELA STAN 1*, CRISTINA TUCHILUŞ 3
1Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universităţii Street, 700115, Iaşi, România
2Faculty of Medicine and Pharmacy, “Dunărea de Jos” University, 35 Al. I. Cuza Street, 800216, Galaţi, România
3Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universităţii Street, 700115, Iaşi, România
*corresponding author: catalinastan68@yahoo.com
#Authors with equal contribution
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Abstract:
The objective of our study was to evaluate the antioxidant and antimicrobial potential for six new azetidin-2-one derivatives
of ferulic acid. The in vitro antioxidant potential of the compounds was assessed by using the total antioxidant capacity and
total reducing power assays. The antimicrobial activity was investigated using Gram positive bacteria (Staphylococcus
aureus ATCC 25923), Gram negative bacteria (Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853) and
pathogenic yeast (Candida albicans ATCC 90028, Candida parapsilosis ATCC 22019). Several of the synthesized
compounds showed a good antioxidant activity, exceeding the ferulic acid antioxidant potential. All the investigated
compounds proved active against Gram positive bacteria.

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