ISOLATION, IDENTIFICATION AND BIOACTIVITY SCREENING OF
TURKISH MARINE-DERIVED FUNGI
HAJAR HEYDARI 1, ASLI KOC 2, DUYGU SIMSEK3, BULENT GOZCELIOGLU 4, NURTEN ALTANLAR 3, BELMA KONUKLUGIL 1*
1Pharmacognosy Department of Ankara University, 06100 Tandoğan, Ankara, Turkey
2Biochemistry Department of Ankara University, 06100 Tandoğan, Ankara, Turkey
3Pharmaceutical Microbiology Department of Ankara University, 06100 Tandoğan, Ankara, Turkey
4Scientific and Technological Research Council of Turkey (TÜBITAK), 06420 Bakanlıklar, Ankara, Turkey
*corresponding author: belma.konuklugil@gmail.com
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Abstract:
Marine-derived fungi are considered as a promising source for discovering new secondary metabolites with pharmaceutical
potential. In this study, 18 marine-derived fungi were isolated and identified from marine invertebrates and investigated with
regard to their antioxidant, antimicrobial and cytotoxic activities. DPPH, SO, NO and ABTS assays were used for monitoring
free radical scavenging activity, and MTT assay was used for cytotoxic activity. For antimicrobial activity determination
minimum inhibitory concentration was calculated. As a result, six Penicillium, five Aspergillus, one Alternaria,
Cladosporium, Malassezia, Mycosphaerella, Sporobolomyces, Talaromyces and Trichoderma species were isolated from the
marine invertebrate. Some of these fungal extracts such as Aspergillus chevalieri has shown high antioxidant and
antimicrobial activities, further Aspergillus awamori, Aspergillus niger and Penicillium brevicompactum have shown
significant cytotoxic activity against HCT-116 cells. This was the first study about habitant of marine-derived fungi of
Turkey’s coasts and their antioxidant, antimicrobial and cytotoxicity activities. Besides, it is also the first report about the
antioxidant and cytotoxicity activities of C. funiculosum, A. awamori and P. crustosum. Antioxidant and antimicrobial
activities of P. rubens were reported for the first time in this study.

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