LACTOBACILLUS REUTERI – AN ALTERNATIVE IN THE FIRST-LINE
OF HELICOBACTER PYLORI ERADICATION
CĂTĂLINA MIHAI 1, BOGDAN MIRCEA MIHAI 2*, MIHAELA DRANGA 1, ANCA CARDONEANU 3, CRISTINA CIJEVSCHI PRELIPCEAN 1
1Institute of Gastroenterology and Hepatology, “Grigore T. Popa” University of Medicine and Pharmacy, “Sf. Spiridon”
Clinical Hospital, Iași, Romania
2Clinical Centre of Diabetes, Nutrition and Metabolic Disease, “Grigore T. Popa” University of Medicine and Pharmacy,
“Sf. Spiridon” Clinical Hospital, Iași, Romania
3Rheumatology, “Grigore T. Popa” University of Medicine and Pharmacy, Rehabilitation Clinical Hospital, Iași, Romania
*corresponding author: bogdanmihai@yahoo.com
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Abstract:
In the context of reduced effectiveness of classical antibiotic regimens in eradicating Helicobacter pylori infection, it is
justified to search for alternative therapies. The present study included 70 patients diagnosed with Helicobacter pylori
infection by the rapid urease test, randomized into two therapeutic regimens: Lactobacillus reuteri DSMZ17648, liquorice
and calcium carbonate and classical proton pump inhibitor - amoxicillin – clarithromycin scheme. The eradication efficiency
was 54.3% in the Lactobacillus reuteri group vs 77.1% in the antibiotic group (p = 0.042) but with a significantly lower rate
of side effects (2.9% vs 17.1%, p = 0.037). Finding new drugs to eradicate Helicobacter pylori with increased efficacy, costeffectiveness
ratio and no side effects remains a challenge.

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