EFFICACY OF ANTIBIOTIC APPROACHES IN NEWBORNS AND
INFANTS WITH NASOLACRIMAL DUCT OBSTRUCTION
ROXANA CALMUSCHI (TRINC) 1,2#, FLORIN ADRIAN SZASZ 3#, SORIN TRINC 2*, SILVIA ROBU 4#, DANA TUTUNARU 4, IONELA DANIELA MORARIU 5#, AFILON JOMPAN 1
1“Vasile Goldiș” Western University of Arad, Faculty of Medicine, Arad, Romania
2Arad County Clinical Hospital, Department of Ophtalmology, Arad, Romania
3University of Medicine and Pharmacy Oradea, Department of Obstetrics-Gynecology, Oradea, Romania
4“Dunărea de Jos” University, Faculty of Medicine and Pharmacy, Galați, Romania
5“Grigore T. Popa” University of Medicine and Pharmacy, Faculty of Pharmacy, Iaşi, Romania
*corresponding author: sorintrinc@yahoo.com
#Authors with equal contribution
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Abstract:
The maximal incidence of nasolacrimal duct obstruction (NLDO) is in new-borns and infants due to the minimal development
and anatomy of the nasolacrimal duct, to the declive predominant position and to the inefficient local cleaning. We analysed
the paraclinical investigations and treatment modalities in patients from Ophthalmology department in Arad County Clinical
Hospital (Arad CCH) between 2016 and 2017. Most of the NLDO patients developed cultures of positive lacrimal secretions,
with or without clinical signs, of which the most common Gram(+) germ (68%) was Staphylococcus aureus (50%) while the
most common Gram(–) germ was Haemophilus influenzae (8.63%) of the total number of patients. These results are similar
to the average quoted in the specialized literature. According to antibiogram, the Gram(+) germs were most susceptible to
Netilmycin and Levofloxacin and Gram(–) germs were the most susceptible to Ciprofloxacin. All patients with visible symptoms
of superinfection of the lacrimal ducts developed positive cultures, while only 33.73% of those with epiphora showed bacterial
growth in conjunctival secretions. It demonstrated the inefficiency of antibiotic treatment in 66.27% of patients with simple
epiphora without first having a specialized ophthalmological examination with analysis of conjunctival secretions. Self-medication
in those cases leads to alteration of lacrimal film composition and uncontrolled resistance to antibiotics.






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