REVISITING THERAPEUTIC SULFONAMIDES IN THE ATTEMPT
TO IMPROVE THE ANTIMICROBIAL PROPERTIES THROUGH
METAL-ION COORDINATION
TAMARA TOPALӐ #, ANDREEA ELENA BODOKI #*, ADRIANA HANGAN, SÎNZIANA GHEORGHE–CETEAN, LUMINIȚA OPREAN
“Iuliu Hațieganu” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of General and Inorganic
Chemistry, 12 Ion Creangӑ Street, 400010, Cluj-Napoca, Romania
*corresponding author: bota@umfcluj.ro
#Authors with equal contribution.
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Abstract:
The serious health issues raised by microbial resistance to first-line and last-resort antibiotics have triggered the search for
efficient strategies to prevent and treat infections. Metal coordination of structures with antibacterial properties represents a
promising approach in improving and refining the biological activity of both antibiotics and metal ions as it provides the
opportunity to design compounds with unique and tunable features. Sulfonamides in particular are an interesting choice since
they combine the structural characteristics required for both antibacterial activity and metal coordination. The present paper
reviews the reports on the antimicrobial properties of complexes of metal ions coordinating sulfonamides widely used in the
therapy of infections over the past decades.

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