DESIGN AND OPTIMIZATION OF FAST DISPERSIBLE
FORMULATIONS OF MULTI STRENGTH MELOXICAM TABLETS
USING RESPONSE SURFACE METHODOLOGY
HUMA ALI 1*, FARYA ZAFAR 2, SOHAIL KHAN 3, RIFFAT YASMEEN 4, RABIA BUSHRA 4, SABA AIJAZ BALOCH 3
1Institute of Pharmaceutical Sciences, Jinnah Sindh Medical University, Karachi, Pakistan
2Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan
3Faculty of Pharmacy, Ziauddin University, Karachi, Pakistan
4DCOP, Faculty of Pharmacy, Dow University of Health Sciences, Karachi, Pakistan
*corresponding author: humaali80@live.com
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Abstract:
The purpose of the current study was to design, develop and optimize fast dispersible tablets (FDT) of meloxicam 7.5 mg and
15 mg. For this, CCRD was used with Design Expert® software. Nine diverse formulations, each of strength (MA1 - MA9;
MB1 - MB9) (F1 - F9) were designed, with two independent variables, including (X1) Croscarmellose (Ac-Di-Sol) (4 - 10%),
(X2) Microcrystalline cellulose (Avicel PH-102) (50 - 65%) at five different levels (1, -1, 0, β, -β). Disintegration time (Y1)
and hardness (Y2) were chosen as responses variables. Powder blends of these trial compositions were evaluated for
micromeritic parameters and finally six formulations from each batch were qualified for compression stage. The selected
formulations were compressed by direct compression procedure. Tablet fill was improved by aspartame, incorporated as a
sweetener. Different compendial and non-compendial tests were carried out to determine the quality attributes of FDT of
Meloxicam and the results were observed within the adequate values. MA6 and MB6 were selected as the preeminent
optimized products on the basis of micromeritic and physicochemical features. MA6 and MB6 have shown quicker
disintegration time i.e. 18 sec; 19 sec and optimal percentage release of drug i.e., 99.38 ± 0.86%; 99.86 ± 0.91% and drug
recovery (assay) values as 100.76 ± 0.52%; 100.01 ± 0.84% respectively. Correspondingly, predicted and actual values of
hardness and disintegration time were found in good correlation. FDTs of Meloxicam were successfully developed using
RSM tool, which was found valuable in discovering the consequences of numerous variables on drug processability.






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