IN VITRO EFFECTS OF SOME SYNTHESIZED AMINOACETANILIDE
N’-SUBSTITUTED ON HUMAN LEUKOCYTES SEPARATED FROM
PERIPHERAL BLOOD
ANA CORINA IONIȚĂ 1, MANUELA GHICA 2, ELENA MOROȘAN 1*, FLORICA NICOLESCU 3, MAGDALENA MITITELU 1
1University of Medicine and Pharmacy “Carol Davila”, Faculty of Pharmacy, Department of Clinical Laboratory and Food
Safety, 6 Traian Vuia Street, 020956, Bucharest, Romania
2University of Medicine and Pharmacy “Carol Davila”, Faculty of Pharmacy, Department of Biostatistics, 6 Traian Vuia
Street, 020956, Bucharest, Romania
3University of Medicine and Pharmacy “Carol Davila”, Faculty of Pharmacy, Department of Toxicology, 6 Traian Vuia
Street, 020956, Bucharest, Romania
*corresponding author: morosan_elena@yahoo.com
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Abstract:
Local anaesthetics are frequently used in several medical areas like surgical interventions, stomatology or preparing the
patient for imagistic techniques like endoscopies. In most cases, the local anaesthetics are administrated in inflammatory
processes and several studies demonstrated that these drugs may influence the response of local immune system cells. The
adverse effects reported are correlated with the route of administration and the interaction with cellular components at the site
of administration. Some lidocaine analogues with aminoacetanilide N’-substituted structure were previously synthesized,
characterized and pharmacologically tested in preclinical studies regarding the local anaesthetic effects and were selected for
the present research. The study aims to determine the effects of the synthetized aminoacetanilide N’-substituted on the release
of oxygen metabolites by polymorfonuclear cells and on the cellular viability of human leukocytes isolated from the
peripheral blood.

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