PHENOLIC SUBSTANCE CONTENTS AND BIOLOGICAL ACTIVITIES
OF VERBASCUM INSULARE BOISS. & HELDR. EXTRACTS
YUSUF ALAN 1*, NIMET YILMAZ 2
1Faculty of Education, Department of Primary Education, Muş Alparslan University, 49250, Muş, Turkey
2Institute of Science, Department of Biology, Muş Alparslan University, 49250, Muş, Turkey
*corresponding author: y.alan@alparslan.edu.tr
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Abstract:
In the present study, 17 different phenolic contents of Verbascum insulare Boiss. & Heldr. ethanolic leaf (LEtOH), aqueous
leaf pure (LPW), ethanolic root (REtOH) and aqueous root pure (RPW) extracts were determined by HPLC. Moreover, their
antimicrobial, antioxidant and DNA protective activities were identified. Curcumin and salicylic acid were not detected in V.
insulare LPW extract, whereas vanillin was not found in RPW extract. The gallic acid and 3,4-dihydroxybenzoic acid
presence were not determined in any extract. Based on the results of the biological activity, it was found that the ethanolic
extract showed a higher antioxidant and antifungal activity compared to pure aqueous extract and increased the DNA
stability. As a result, it may be argued that the biological activity of the ethanolic extract is higher due to the total phenolics
compared with the aqueous extract. Since no previous studies were available on the biological activities of this plant, the data
obtained in the present study will contribute to future pharmacological studies.

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