WATER STRUCTURING EFFECT OF METHANOL AND ETHANOL
ON ION PAIRING OF SOME GUANIDIUM CONTAINIG
PHARMACEUTICAL SUBSTANCES. ANALYTICAL APPLICATIONS
MARINELA FLOREA1, IOANA CLEMENTINA CONSTANTINESCU 1*, ANGELA NEDELCU 1, CLAUDIA-MARIA GUȚU 2, MAHER ABDULRAZZAQ LUQMAN AL-HAKEEM 3, LĂCRĂMIOARA POPA 3
”Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, 6 Traian Vuia Street, 020956, Bucharest, Romania
1Department of Analytical Chemistry
2Department of Toxicology
3Department of Physical and Colloidal Chemistry
*corresponding author: constantinescu_clementina@yahoo.com
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Abstract:
The influence of water structuring effect of methanol and ethanol on ion pairing of two guanidinum containing pharmaceutical
compounds, namely streptomycin and arginine, was studied. Congo red was used as counterion. For this purpose, the molecular
modelling, physico-chemical constants (dielectric constant, conductivity) and absorption and resonance light scattering spectrometry
were used. Determinations were performed using water/alcohol binary solvent mixtures containing molar fractions of 0.05
methanol, respectively 0.03 ethanol. The results showed that, in low concentrations, methanol and ethanol favours ion pairing.
For streptomycin, analytical applications were studied.

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