CURRENT VIEW ON VITAMIN K2 ROLE IN DISEASES BASED ON
CLINICAL TRIALS
PIOTR JAKUBOWSKI 1*, ŁUKASZ SMYK 1, ŁUKASZ PUCHAŁA 2, JOANNA BIAŁKOWSKA 3
1Department of Pharmacology and Toxicology, School of Medicine, University of Warmia and Mazury in Olsztyn, 30
Warszawska Street, 11-041 Olsztyn, Poland
2Department of Medical Biology, Faculty of Health Sciences, University of Warmia and Mazury in Olsztyn, 14C Żołnierska
Street, 10-900 Olsztyn, Poland
3Department of Public Health, Faculty of Health Sciences, University of Warmia and Mazury in Olsztyn, 14C Żołnierska
Street, 10-900 Olsztyn, Poland
*corresponding author: piotr.jakubowski@uwm.edu.pl
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Abstract:
Vitamin K2 is found in fermented foods such as dairy products, natto (fermented soybeans) and some animal products. It has
been shown that it can be beneficial in many diseases. Most of the data refer to the use of this vitamin in osteoporosis, for
instance, low frequency of hip fractures in Japan is correlated with significant consumption of natto. Also, long-term
supplementation of vitamin K2 decreased loss of bone mass in postmenopausal women. Vascular calcification can be
prevented by high dietary intake of vitamin K2 and also patients undergoing dialysis may benefit from supplementation.
Besides this conditions, vitamin K2 may be applicable in diabetes mellitus type 2, cancer (especially prostate and breast) or
multiple sclerosis. The great advantage of this vitamin is its low toxicity and favourable pharmacokinetics.

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