STUDY ON THE CONCENTRATE OF PROTEOLYTIC ENZYMES
ENRICHED IN BROMELAIN AND ITS EFFECTS ON INTERMEDIATE
AND EXTENSIVE BURNS
SILVIU ADRIAN MARINESCU 1,2#, CĂTĂLIN GHEORGHE BEJINARIU 2*, ANA-MARIA BOIANGIU 2, DRAGOȘ GEORGESCU 1,3#, ALICE BĂLĂCEANU 1,4#, FLORENTINA GHERGHICEANU 1,5, CARMEN GIUGLEA 1,6
1“Carol Davila” University of Medicine and Pharmacy, Faculty of General Medicine, 6 Traian Vuia Street, 020956, Bucharest,
Romania
2“Bagdasar-Arseni” Emergency Clinical Hospital, Department of Plastic and Reconstructive Surgery, 12 Berceni Road,
041915, Bucharest, Romania
3“Sfântul Ioan” Emergency Clinical Hospital, 13 Vitan-Bârzești Road, 042122, Bucharest, Romania
4“Sfântul Ioan” Emergency Clinical Hospital, Department of Internal Medicine, 13 Vitan-Bârzești Road, 042122, Bucharest,
Romania
5Department of Marketing and Medical Technology, 8 Eroii Sanitari Boulevard, 050474, Bucharest, Romania
6“Sfântul Ioan” Emergency Clinical Hospital, Department of Plastic and Reconstructive Surgery, 13 Vitan-Bârzești Road,
042122, Bucharest, Romania
*corresponding author: drbejinariu@gmail.com
# Authors with equal contribution.
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Abstract:
The present study aimed to highlight the effects of the enzymatic debridement (ED) with a concentrate of proteolytic
enzymes enriched in bromelain (CPE-B) on intermediate and extensive burns including facial and upper limbs. In order to
carry out the study, the therapeutic protocol recommended by the producer was used and, as an extension of the indications,
CPE-B was applied in multiple stages in the case of extensive burns and those located at the level of the cephalic extremity
and hands. ED with CPE-B has proven to be an effective and selective method, having a significant impact on reducing
hospitalization time, as well as reducing treatment costs, improving post-burn scarring and finally improving the patients’
degree of satisfaction.

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