MELATONINE AND ERYTHROPOIETIN PREVENTS GENTAMICIN
INDUCED NEPHROTOXICITY IN RATS
ANDREI RĂZVAN CODEA 1, MIRCEA MIRCEAN 1*, ANDRAS NAGY 1, ORSOLYA SARPATAKY 1, BOGDAN SEVASTRE 1, ROXANA LIANA STAN 2, ADRIANA CORINA HANGAN 2, CRISTIAN POPOVICI 1, DANIELA NEAGU 1, ROBERT PURDOIU 1, ALEXANDRA BIRIȘ 1, RODICA UNGUR 3, OANA LIVIU 1
1Faculty of Veterinary Medicine, University of Agricultural Science and Veterinary Medicine, 3-5 Mănăștur Street, Cluj-Napoca, Romania,
2“Iuliu-Hațieganu” University of Medicine and Pharmacy, Faculty of Pharmacy, 8 Victor Babeș Street, Cluj-Napoca, Romania
3“Iuliu-Hațieganu” University of Medicine and Pharmacy, Faculty of General Medicine, 8 Victor Babeș Street, Cluj-Napoca, Romania
*corresponding author: mircea.mircean@usamvcluj.ro
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Abstract:
Melatonin (MLT) is an epiphyseal chronobiotic hormone, also known for its antioxidant effects. Besides erythropoiesis,
erythropoietin (EPO) possesses other biological functions (neuroprotection, nephroprotection). We focused on the assessment
of MLT and EPO nephroprotective effects in a gentamicin (GM) toxicity model. Forty adult male Wistar rats were divided
into 5 groups: control, GM, EPO + GM, MLT + GM and MLT + EPO + GM, consisting of 8 rats each. Chemicals were
administered for 10 days, daily, by i.p. route. Both MLT and EPO prevented kidney damage reflected by lower urinary Nacetyl-
β-d-glucosaminidase (NAG) activity index, reduced kidney structural damage, increased urinary density and decreased
blood urea and creatinine concentrations. The best protective effect was provided by MLT and EPO association.

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