PHENOLIC COMPOUNDS OF SERRATULA CENTAUROIDES AND
ANXIOLYTIC EFFECT
SERGEI MATVEEVICH NIKOLAEV 1,3, IRINA GENNADYEVNA NIKOLAEVA 1,2*, YANINA GENNADYEVNA RAZUVAEVA 1,2, IRINCHEI EDUARDOVICH MATKHANOV 1, LILIYA PURBUEVNA TSYBIKTAROVA 2, LARISA NIKOLAEVNA SHANTANOVA 1,2, GALINA GRIGORYEVNA NIKOLAEVA 1,2
1Institute of General and Experimental Biology SB RAS (IGEB SB RAS), 6 Sakhynovoi Street, 670047, Ulan-Ude, Russia
2Buryat State University (BSU), 24a Smolina Street, Ulan-Ude, Russia
3Irkutsk State Medical Academy of Postgraduate Education - Branch Campus of the Russian Medical Academy of Continuing
Professional Education, 100 Yubilejnyj, Irkutsk, Russia
*corresponding author: i-nik@mail.ru
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Abstract:
The paper presents the results of the study of a dry extract of Serratula centauroides (Asteraceae) using a HPLC method and
estimation of his anxiolytic activity. 17 phenolic substances and 15 respectively were identified in the herb in the roots. In the
herb of the plant, there were revealed hyperoside and luteolin. The aerial part contains twice as much ecdysterone as the roots
of S. centauroides. The experiments conducted on animals have shown that the S. centauroides dry extract at the doses
comprised between 50 - 150 mg/kg bw has a marked anxiolytic effect. S. centauroides extract increases the number of entries
into the open branches of elevated plus maze (EPM) and prolongs a residence time in the open arms of EPM and light
compartment of the dark/light chamber. The use of S. centauroides increases the number of punished water intakes in the
Vogel conflict test.

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