ANTIMICROBIAL ASSAY OF A CAPSAICIN - α-CYCLODEXTRIN
INCLUSION COMPLEX AGAINST PLANKTONIC AND ADHERENT
CELLS
FELICIA CIULU-COSTINESCU 1, PAULINA PODGOREANU 1*, CRISTINA DELCARU 1, ANDREEA SIMIONESCU 2, EUGEN FLORIN GEORGESCU 3, MARINELA BOSTAN 4, MARIANA-CARMEN CHIFIRIUC 1
1Research Institute of the University of Bucharest (ICUB), Earth, Environmental and Life Sciences Division, University of
Bucharest, 36-46 M. Kogălniceanu Boulevard, 050107, Bucharest, Romania
2Faculty of Exact Sciences, Department of Chemistry, University of Craiova, 107 Calea București Street, 200515, Craiova, Romania
3Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Petru Rareș Street, 200349, Craiova, Romania
4Center of Immunology, “Ștefan S Nicolau” Institute of Virology, 285 Mihai Bravu, 030304, Bucharest, Romania
*corresponding author: podgoreanu.paula@yahoo.com
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Abstract:
Capsaicin (CAP), (E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide, as an active principle and α-cyclodextrin
(α-CD) have been used to obtain an inclusion complex with the molar ratio 1:1 that can be subsequently included in
semisolid pharmaceutical formulations in order to improve the solubility of this active principle. In the inclusion process no
covalent bonds are formed or broken. The results of the antimicrobial activity assay revealed a similar efficiency of the two
capsaicin complexes and of non-capsulated CAP against planktonic cells. However, the inclusion complex of capsaicin
significantly improves its antibiofilm activity, is thus recommended for the development of preventive or therapeutic
strategies for the management of biofilm-associated infections.

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