PROTECTIVE EFFECT OF ELLAGIC ACID IN VASCULAR
EPOXIDATION DAMAGE IN A MURINE MODEL OF
ATHEROSCLEROSIS
YANHUA XIONG 1, WENPING ZENG 2*
1Internal Medicine of Traditional Chinese Medicine, Zhejiang Hospital, Hangzhou, 310007, China
2Department of Cardiology, Zhejiang Hospital, Hangzhou, 310007, China
*corresponding author: zengwenping2125@163.com
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Abstract:
In order to explore the mechanism underlying the protective effect of ellagic acid (EA) against vascular dysfunction and
oxidative damage in vascular endothelial cells, a high-fat diet (HFD) murine model was established using 32 ApoE-/- mice
and 32 wild type C57BL/6 mice (WT). The degree of atherosclerosis, blood biochemical parameters, the expression of nitric
oxide synthase (NOS), the expression of Nrf2 (nuclear factor (erythroid derived 2) like 2) and HO-1 (heme oxygenase-1)
proteins were analysed. In addition, the protective effect of EA against oxidative damage in mouse vascular endothelia was
studied by detecting the relaxation status of vascular endothelia. The results showed that the plaque area of atherosclerosis
decreased significantly in mice treated with EA by increasing the expression of Nrf2 and HO-1 in blood vessels. The level of
Nrf2 and HO-1 proteins in the arteries of WT mice and ApoE-/- mice treated with EA were significantly increased, suggesting
that EA improves vasodilation by increasing Nrf2 expression.

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