MONITORING THE EFFECTS OF VARIOUS COMBINATION OF
SPECIFIC DRUG THERAPIES AT DIFFERENT STAGES OF
ALZHEIMER′S DEMENTIA
LAVINIA PURZA 1,2, MOHAMED ABDEL-DAIM 3,4, ADRIANA BELBA 2, CIPRIAN IOVAN 2*, ADRIAN BUMBU 2, LIVIU LAZĂR 2, SIMONA BUNGĂU 2, DELIA MIRELA ȚIȚ 2
1University of Oradea, Doctoral School of Biomedical Sciences, 1 Universităţii Street, 410087, Oradea, Romania
2University of Oradea, Faculty of Medicine and Pharmacy, 10 P-ţa 1 Decembrie Street, 410073, Oradea, Romania
3Suez Canal University, Faculty of Veterinary Medicine, Pharmacology Department, Egypt
4Yokohama City University, Department of Ophthalmology and Micro-Technology, Yokohama, Japan
*corresponding author: dr.iovan@biostandard.ro
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Abstract:
We have studied the effects of various combinations of specific drug therapies on patients with Alzheimer′s dementia. The
study was conducted over a 12-week period, with initial, after 4, 8, and 12-weeks assessment. A number of 140 patients with
Alzheimer′s dementia were assessed observing the clinical manifestations, the therapeutic measures that were applied and the
changes in the response to treatment. Mini-Mental State Examination (MMSE) was used to monitor the cognitive
functionality evolution of the studied patients. The depreciation of the MMSE score was observed in 2.94% of the patients
registering a mild impairment, in 6.02% - a moderate impairment and 17.39% - a severe impairment. The greatest
depreciation effect was achieved with memantine in monotherapy (ES = 0.24), and the lowest - with donepezil therapy in
combination with memantine (ES = 0.24). Our results prove that specific anti-dementia treatment is effective for the
treatment of cognitive impairment, especially if it is instituted at the onset of the disease.

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