INTRODUCING VEGETABLE OILS IN A PREPARATION OF
KETOCONAZOLE LIPOSOMES USING A THIN-FILM HYDRATION
METHOD
OLGA POPOVSKA 1*, ZORAN KAVRAKOVSKI 2, VESNA RAFAJLOVSKA 1
1Ss. Cyril and Methodius University in Skopje, Faculty of Technology and Metallurgy, Rudjer Boskovic 16, 1000 Skopje,
Republic of Macedonia
2Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy, Majka Tereza 47, 1000 Skopje, Republic of Macedonia
*corresponding author: olga_popovska@yahoo.com
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Abstract:
Multilamellar ketoconazole liposome vesicles (MLV) were prepared using a thin-film hydration method. Sunflower and olive
oil were introduced as solvents in a preparation of ketoconazole liposomes. The liposomes were evaluated by determination of
morphological characteristics, encapsulation efficiency of ketoconazole and ζ-potential. The highest encapsulation efficiency
was found to be 91.21% in the ratio of ketoconazole, cholesterol, and L-α-phosphatidylcholine 3.33:1:3.33 w/w/w.






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