EQUESTRIAN SYNOVIAL FLUID MESENCHYMAL STEM CELLS, A
POTENTIAL EXPERIMENTAL MODEL FOR OSTEOARTICULAR
THERAPIES
CRISTIAN MIHĂIȚĂ CRECAN 1#, SIMONA LUMINIȚA OPREAN 2*, MIRELA ALEXANDRA TRIPON 3, ANDREI BODNARIUC 4, LUCIANA RUS 5, EMOKE PALL 3#, DANIELA CLAUDIA OROS 6, IANCU MORAR 3#
1University of Agricultural Sciences and Veterinary Medicine, Faculty of Veterinary Medicine, Department of Surgical
Techniques, 3-5 Mănăştur Street, 400372, Cluj-Napoca, Romania
2“Iuliu Hațieganu”, University of Medicine and Pharmacy, Faculty of Pharmacy, Department of General and Inorganic
Chemistry, Cluj-Napoca, Romania
3University of Agricultural Sciences and Veterinary Medicine, Faculty of Veterinary Medicine, Department of Reproduction
and Obstetrics, 3-5 Mănăştur Street, 400372, Cluj-Napoca, Romania
4University of Agricultural Sciences and Veterinary Medicine, Faculty of Veterinary Medicine, Department of Pathophysiology,
3-5 Mănăştur Street, 400372, Cluj-Napoca, Romania
5University of Agricultural Sciences and Veterinary Medicine, Faculty of Veterinary Medicine, Department of Parasitology,
3-5 Mănăştur Street, 400372, Cluj-Napoca, Romania
6Private Practitioner, Cluj-Napoca, Romania
*corresponding author: lopreans@umfcluj.ro
#Authors with equal contribution
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Abstract:
Mesenchymal stem cells (MSCs) therapy has become widely used to treat degenerative diseases. There are various tissue
specific sources of stem cells with different therapeutic applications, therefore it is necessary to further investigate the
characteristics and differences between MSCs from different origins, their potential and limitations. Osteoarthritis is the most
common joint disease affecting both human and horses, and current treatment options have strong limitations. The use of
MSCs to treat degenerative osteo-articular diseases has proven to be effective but further studies are needed to establish the
safest and most effective protocol with regard to source, allogenic versus autologous cells and dose. Horses can be used as a
large animal model for in vivo testing, due to some joint structural similarities. In the current study we compared the
characteristics of synovial fluid-derived mesenchymal stem cells (SF-MSCs) harvested from horses with different joints
degenerative diseases, to those observed in injured human joints. The results of this study showed that SF-MSCs from injured
horse joints have substantial chondrogenic potential and they show great similarities to those observed in humans.

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