SUPERCRITICAL FLUID TECHNOLOGY AND SUPERCRITICAL FLUID
CHROMATOGRAPHY FOR APPLICATION IN GINSENG EXTRACTS
MAYYA PETROVNA RAZGONOVA 1, ALEXANDER MIKHAILOVICH ZAKHARENKO 1, TATIANA KUZMINICHNA KALENIK 2, ALEXANDER EVGENYEVICH NOSYREV 3, ANTONIS K. STRATIDAKIS 4, YAROSLAV OLEGOVYCH MEZHUEV 5, TATYANA I. BURYKINA 6, ALINA CRENGUȚA NICOLAE 7, ANDREEA LETIȚIA ARSENE 7, ARISTIDIS MICHAEL
TSATSAKIS 3,4,5, KIRILL SERGEYEVICH GOLOKHVAST 1,8*
1Scientific Education Center in Nanotechnology, Far-Eastern Federal University, Vladivostok, Far East, Russian Federation
2School of Biomedicine, Far-Eastern Federal University, 690950, Vladivostok, Far East, Russian Federation
3Central Chemical Laboratory of Toxicology, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation
4Laboratory of Toxicology, School of Medicine, University of Crete, Heraklion 71003, Greece
5Dmitry Mendeleev University of Chemical Technology of Russia, Miusskaya Square, 9, Moscow 125047, Russian Federation
6Department of Analytical and Forensic Medical Toxicology, Sechenov University, Moscow 119991, Russian Federation
7Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
8Pacific Geographical Institute FEB RAS, 7 Radio street, Vladivostok, 690041, Russian Federation
*corresponding author: golokhvast.ks@dvfu.ru
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Abstract:
This research review deals with the study of the scientific articles, published during the last two decades that are devoted to
the extraction of ginsenosides from different types of ginseng with the use of supercritical CO2(SC - CO2). Different types of
ginseng are being the object of investigation including Panax ginseng C.A. Meyer, Brazilian ginseng (Pfaffia paniculata,
Pfaffia glomerata, Hebanthe eriantha) and North American ginseng (Panax quinquefolius). It was shown that the extraction
and fractionation of Panax ginseng C.A. Meyer using SC-CO2 technology is a very effective way for extracting biologically
active plant components, such as ginsenosides, kudinosides, polysaccharides, polyphenolic compounds and stauntosides. In
addition, it was exhibited that SC-CO2 technology could increase considerably the yield in antioxidant fractions in which the
concentration of bioactive components of a P. ginseng C.A. Meyer are high. At last, this review also considers the application
of supercritical CO2 fluid chromatography for Panax ginseng. The review aspired to investigate the contents and to compare
other ways of extraction with supercritical extraction and to show its efficiency and also use of new “green technologies”.

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