THE EFFECTS OF NEW 1,3-THIAZOLIDINE-4-ONES WITH
PYRRAZOLONE SCAFOLD ON MOTOR FUNCTION IN MICE
MARIA APOTROSOAEI 1, IOANA MIRELA VASINCU 1*, SANDRA MĂDĂLINA CONSTANTIN 1, ANDREEA-TEODORA IACOB 1, GEORGIANA-ROXANA TAUȘER 1, DAN LUPAȘCU 1, CĂTĂLINA-ELENA LUPUȘORU 2, LENUȚA PROFIRE 1
1”Grigore. T. Popa” University of Medicine and Pharmacy Iași, Faculty of Pharmacy, Department of Pharmaceutical Chemistry,
Universității Street, no. 16, 700115, Iași, Romania
2”Grigore. T. Popa” University of Medicine and Pharmacy Iași, Faculty of Medicine, Department of Pharmacology, Clinical
Pharmacology and Algesiology, Universității Street, no. 16, 700115, Iași, Romania
*corresponding author: ioana-mirela.vasincu@umfiasi.ro
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Abstract:
The aim of this study was to investigate the effects of new 1,3-thizolidine-4-ones with pyrazolone scaffold (7a-m) on motor
function in mice, using RotaRod performance and spontaneous locomotor activity tests. The toxicity screening of these
compounds was also performed. The results of RotaRod performance test showed that the compounds don’t have appreciable
negative influence on neuromuscular activity, the recorded values being comparable with those of phenazone and control, so
it could be appreciated that these compounds don’t have neurotoxic effects. In the case of spontaneous locomotor activity
test, the most intense negative effect was observed for 7j (3-OH,4-OCH3), for which the horizontal and vertical movements
were lower than phenazone and control at all three-time intervals (1h, 2h, 4h). For other derivatives no appreciable negative
effect on spontaneous locomotor activity was observed. Referring to the toxicity degree, all tested compounds showed lower
toxicity in reference with phenazone, which supports the favourable influence of 1,3-thiazolidine-4-one moiety on pyrazolone
scaffold.

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