THE BEHAVIORAL STUDY OF THE EFFECTS OF ATRISTAMINE ON
THE SEROTONIN, DOPAMINE AND NOREPINEPHRINE
NEUROTRANSMITTER SYSTEMS IN MICE
ILLYA PODOLSKY *, SERGIY SHTRYGOL′
National University of Pharmacy, Kharkiv, Ukraine
*corresponding author: illya.podolsky@nuph.edu.ua
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Abstract:
The present work reports the behavioural study of the effects on the serotonin, dopamine and norepinephrine neurotransmitter
systems of 2-methyl-3-(phenylaminomethyl)-1H-quinolin-4-one (atristamine), a novel promising substance that exhibits
excellent antidepressant effect combining with additional valuable neurotropic properties. The results indicate that the acute
administration of atristamine increases the responsiveness of the adrenergic system. It has been proven by enhancement of
clonidine-induced aggressive behaviour and attenuation of clonidine-induced depression in mice. It has been shown that
atristamine attenuates haloperidol-induced catalepsy in mice, but this effect does not associate with MAO and COMT
inhibition. A mild modulating effect of atristamine on the serotonin neurotransmitter system was discovered using 5-HTP
induced head-twitch response in mice. It has been concluded that the antidepressant effect of atristamine may be explained
predominantly by its complicated influence on the serotonin, dopamine and norepinephrine neurotransmitter systems.

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