DESIGNING NEW MOTHER TINCTURES FOR INCREASED
ANTIOXIDANT EFFICIENCY ON INFLAMMATORY INTESTINAL
DISEASES
SORINA NICOLETA VOICU 1, ANCA HERMENEAN 2,3, NELI-KINGA OLAH 4,5, LILIANA BADULESCU 6, MIRUNA SILVIA STAN 1*, ANCA DINISCHIOTU1
1Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 91-95 Splaiul Independentei,
050095 Bucharest, Romania
2The Institute of Life Sciences, “Vasile Goldiș” Western University of Arad, Arad, Romania
3Department of Histology, Faculty of Medicine, “Vasile Goldiș” Western, University of Arad, Arad
4SC PlantExtrakt SRL, 407059 Rădaia, Cluj-Napoca, Romania
5“Vasile Goldiș” Western University of Arad, Faculty of Pharmacy, 86 L. Rebreanu, 310414 Arad, Romania
6Department of Bioengineering of Horticulture Systems, University of Agronomic Sciences and Veterinary Medicine, 59
Mărăști Boulevard, 011464 Bucharest, Romania
*corresponding author: miruna.stan@bio.unibuc.ro
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Abstract:
Four mother tinctures of Filipendula ulmaria, Fraxinus excelsior, Gaultheria procumbens and Populus tremula were
characterized from the point of view of the antioxidant effect, and were tested in vitro on colon cell cultures in order to select
the most potent extracts for intestinal inflammatory pathologies. The antioxidant capacity of the selected tinctures was
determined by measuring 2,2-diphenyl-1-picryl-hydrazyl (DPPH)-radical-scavenging activity, oxygen radical absorbance
capacity (ORAC) and nitric oxide radical scavenging activity. Our results showed that all extracts exhibited antioxidant
capacity, but the greatest effect was observed for Filipendula ulmaria. In addition, it was revealed that they were not
cytotoxic to intestinal Caco-2 cells, our findings providing valuable information for introducing these tinctures on the
Romanian market of homeopathic products.

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